Swiss nude

Swiss nude Spontaneous Mutant Mouse Model
  • Cryopreserved
  • Mouse
  • Albino
  • Albino nude
Model No.NomenclatureGenotype
NSWNU NTac:NIHS-Foxn1nusp/sp
NSWNU-M NTac:NIHS-Foxn1nusp/sp
NSWNU-F NTac:NIHS-Foxn1nusp/wt
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Overview

Nomenclature: NTac:NIHS-Foxn1nu

  • An outbred athymic model originating from the NIH Genetic Repository
  • This outbred stock is frequently used for implants of human tumors for purposes of chemotherapeutic screening
  • Maintained in flexible-film isolators under gnotobiotic conditions
  • The autosomal recessive nude gene in homozygous (sp/sp) mice causes the lack of fur and an abnormal thymus. The deficiency in T cell function allows athymic mice to accept and grow xenografts as well as allografts of normal and malignant tissues.
  • Heterozygous (sp/wt) mice carry only one copy of the nude mutation and have hair. Heterozygous nudes were originally thought to have normal immune systems, but in fact have immune alterations such as reduced bone marrow stem cells and lower thymus weights. Heterozygous nudes may thus not be appropriate for use as sentinels. They may be used in PK/dosing studies.

Origin

Taconic received the Swiss nude Spontaneous mutant model from the NIH Animal Genetic Resource in 1976. The mice were derived by hysterectomy in 1989 and are maintained in gnotobiotic isolators on strict defined flora.

Genetics

Species:Mouse
Strain Type:Outbred or Mixed
Allele Type:Spontaneous Mutant
Coat Color:Albino nude;Albino
Coat Color Loci: Tyrc
Coat Color Loci: Tyrc

Guides & Publications

Applications & Therapeutic Areas

  • Immunology
  • Oncology & Immuno-Oncology
  • Inflammation

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