Application Areas:
Live production of model 584 has ceased. This model is now available via Taconic’s Cryopreserved Repository. Customers who need continued access may inquire about licensing options for in-house breeding or cryorecovery. Line 583 remains available as an alternative.
Fcer1g - Model 584
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- Description
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- Price & Licensing
- Overview
- Genetics
- Guides & Publications
- Applications & Therapeutic Areas
Overview
Nomenclature: C.129P2(B6)-Fcer1gtm1Rav N12
- Deficient in the gamma chain subunit of the FcgRI, FcgRIII, and FceRI receptors
- The deleted gamma chain subunit is essential for cell surface expression of these molecules
- Macrophages, neutrophils, mast cells, basophils, and NK cells are functionally impaired, due to the lack of these Fc receptors
- The mice have normal T cell thymic and peripheral T cell development
- Useful in determining the role of structurally similar Fc receptors in mediating effector immune responses and studying the pleiotropic role of the γ chain subunit
- Exhibit several different types of immunodeficiency making them useful for studies to distinguish the role of the Fc Receptors in antibody-mediated effector responses and to evaluate the contribution of IgG and IgE triggered effector pathways
- The mice are fertile and develop normally
- These mice carry the H2d haplotype
Recommended Controls
The recommended control for this model is BALB/cAnNTac.
Origin
The Fcer1g mouse was developed in the laboratory of J.V. Ravetch in 1993. The model was created by targeting the Fcer1g gene in E14 ES cells and injecting the targeted cells into C57BL/6 blastocysts. Heterozygotes on a C57BL/6 background were intercrossed to generate homozygous targeted mutation mice. The mice were then backcrossed twelve generations (N12) to a BALB/cByJ inbred background. The mice were further backcrossed to the BALB/cAnNTac inbred strain to NE10. Taconic received stock in 1996. The mice were derived by embryo transfer in July 1997 and are maintained by incrossing homozygous mice.
Genetics
Guides & Publications
Initial Publication:
Takai T, Li M, Sylvestre D, Clynes R, Ravetch J. (1994) FcRγ Chain Deletion results in Pleiotrophic Effector Cell Defects. Cell, 76:519-529.
Applications & Therapeutic Areas
- Autoimmune Disease
- Immunology
- Inflammation
- Oncology & Immuno-Oncology
- Vaccine Research
- Services
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Fcer1g - Model 584
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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