Cdh5(PAC)-CreERT2 Mouse

Cdh5(PAC)-CreERT2 Random Transgenic Mouse Model
  • Live
  • Mouse
  • Male & Female Available
  • Black
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
13073C57BL/6-Tg(Cdh5-cre/ERT2)1Rha
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Overview

Nomenclature: C57BL/6-Tg(Cdh5-cre/ERT2)1Rha

  • An inducible cre deleter under the control of the vascular endothelial cadherin (Cdh5(PAC)) promoter
  • Cre recombination is inducible via administration of tamoxifen
  • Useful for study of angiogenesis, atherosclerosis and neovascularization
  • Non-induced Cdh5(PAC)-CreERT2 mice demonstrate no Cre recombinase activity, while tamoxifen-induced Cdh5(PAC)-CreERT2 mice demonstrate high levels of recombinase-mediated gene deletion in vascular endothelial cells (95%+).
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Availability

Limited quantities of breeders are available for purchase after execution of a license.

Ordering Note: Animals ordered at 4 weeks of age require rapid genotyping and a $40.00 per mouse charge will be added.

Origin

The Cdh5(PAC)-CreERT2 Mouse was developed in the laboratory of Ralf Adams at the London Research Institute. The model was generated by microinjecting a transgene containing a genomic Cdh5(PAC) promoter fragment fused to a CreERT2 cDNA into C57BL/6 zygotes. Founder lines were backcrossed to C57BL/6 for at least five generations. Taconic received embryos from CRT in 2013.

Source: Cancer Research Technology

Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Recombinase-expressing;Random transgenic
Coat Color:Black
Genetic Background:C57BL/6

Guides & Publications

Initial Publication: 

Sörensen I, Adams RH, Gossler A. (2009) DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood. 113(22):5680-8.

Applications & Therapeutic Areas

  • Cardiovascular Disease
  • Oncology & Immuno-Oncology
  • Recombinase-mediated Gene Deletion

Transit, Housing & Welfare

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Licensing

To purchase this model, sign the Terms of Sale (choose from the list below) and email it directly to legal@taconic.com:

This model is sold under terms which grant perpetual use rights. Live mice may be purchased once the Terms of Sale have been executed and a form of payment provided for the license fee.

Pricing - USD

Murine Pathogen Free™ (MPF™)

13073 - Female

13073 - F Genotype tg/wt
Age in WeeksQuantity 1-999
4 to 10$353.10

13073 - Male

13073 - M Genotype tg/wt
Age in WeeksQuantity 1-999
4 to 10$353.10

13073

ItemCommercialNonprofit
Cryopreserved$30,000.00$9,000.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - EUR

Murine Pathogen Free™ (MPF™)

13073 - Female

13073 - F Genotype tg/wt
Age in WeeksQuantity 1-999
4 to 10€323.73

13073 - Male

13073 - M Genotype tg/wt
Age in WeeksQuantity 1-999
4 to 10€323.73

13073

ItemCommercialNonprofit
Cryopreserved€27,000.00€8,000.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - USD Nonprofit

Murine Pathogen Free™ (MPF™)

13073 - Female

13073 - Male


13073

ItemCommercialNonprofit
Cryopreserved$30,000.00$9,000.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - EUR Nonprofit

Murine Pathogen Free™ (MPF™)

13073 - Female

13073 - Male


13073

ItemCommercialNonprofit
Cryopreserved€27,000.00€8,000.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

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Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.