Pirc

Pirc ENU-induced mutant Rat Model
  • Cryopreserved
  • Rat
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
PIRCF344/NTac-Apcam1137ki/wt
PIRC-MF344/NTac-Apcam1137ki/wt
PIRC-FF344/NTac-Apcam1137wt/wt
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Overview

Nomenclature: F344/NTac-Apcam1137

  • Excellent model for study of human familial colon cancer
  • ENU-induced point mutation results in a truncating mutation in the Apc gene at a site corresponding to the human mutation hotspot region of the gene
  • Heterozygotes develop multiple tumors in the small intestine and colon by 2-4 months of age
  • Pirc tumors closely resemble those in humans in terms of histopathology and morphology as well as distribution between intestine and colon
  • Longer lifespan compared to related mouse models (10-15 months)
  • Tumors may be visualized by CT, endoscopy or dissection

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Rat
Strain Type:Inbred
Allele Type:ENU-induced Mutant
Genetic Background:F344

Guides & Publications

Initial Publication: 

  • Amos-Landgraf JM, Kwong LN, Kendziorski CM, Reichelderfer M, Torrealba J, Weichert J, Haag JD, Chen K-S, Waller JL, Gould MN, Dove WF. (2007) A target-selected Apc-mutant rat kindred enhances the modeling of familial colon cancer. Proc Natl Acad Sci USA 104(10):4036-4041.
  • Amos-Landgraf JM, Irving AA, Hartman C, Hunter A, Laube B, Chen X, Clipson L, Newton MA, Dove WF. (2012) Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms. Proc Natl Acad Sci U S A. 109(6):2060-5.
Other publications: Femia AP, Luceri C, Soares PV, Lodovici M, Caderni G. (2014) Multiple mucin depleted foci, high proliferation and low apoptotic response in the onset of colon carcinogenesis of the PIRC rat, mutated in Apc. Int J Cancer. 2014 Sep 25. [Epub ahead of print]

Applications & Therapeutic Areas

  • Oncology & Immuno-Oncology

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Pirc

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.

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Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.