Pfp/Rag2

Pfp/Rag2 Constitutive Knockout Mouse Model
  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
1177B6.129S6-Rag2tm1FwaPrf1tm1Clrk N12
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Overview

Nomenclature: B6.129S6-Rag2tm1FwaPrf1tm1Clrk N12

  • This double targeted mutation contains a disruption of both Rag2 and Pfp genes
  • Exhibits a severe depletion of NK cell function through the disruption of the Pfp gene and lacks mature T or B lymphocytes through disruption of the Rag2 gene
  • Used to study overall regulation of the immune system or specific areas such as NK or CTL activity, immune suppression and transplantation
  • Carries the H2b haplotype

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse
Strain Type:Congenic
Allele Type:Constitutive Knockout
Genetic Background:C57BL/6

Other Genetic Notes:

Wild type for Nnt mutation

Guides & Publications

Initial Publication: Shinkai, Y, Rathbun, G, Lam, KP, Oltz, EM, Stewart, V, Mendelsohn, M, Charron, J, Datta, M, Young, F, Stall, AM, and Alt, FW. (1992) RAG-2-Deficient Mice Lack Mature Lymphocytes Owing to Inability to Initiate V(D)J Rearrangement, Cell, 68: 855-867.

Walsh CM, Matloubian M, Liu C, Ueda R, Kurahara CG, Christensen JL, Huang MTF, Young JD, Ahmed R, and Clark WR. (1994) Immune function in mice lacking the perforin gene. Proc Natl Acad Sci USA, 91(23): 10854-10858.

Applications & Therapeutic Areas

  • Immunology
  • Oncology & Immuno-Oncology
  • Inflammation

Transit, Housing & Welfare

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Pfp/Rag2

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.

Pricing - USD

1177

ItemCommercialNonprofit
Cryopreserved Model$23,100.00$17,325.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - EUR

1177

ItemCommercialNonprofit
Cryopreserved Model€21.000,00€15.855,00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

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Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.