Humanized OATP1B1 Mouse

Humanized OATP1B1 Constitutive Knockout Mouse Model
  • Cryopreserved
  • Mouse
  • Albino
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
10708FVB.129P2-Del(Slco1b2-Slco1a5)1Ahs Tg(APOE-SLCO1B1)1Ahs
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Overview

Nomenclature: FVB.129P2-Del(Slco1b2-Slco1a5)1Ahs Tg(APOE-SLCO1B1)1Ahs

  • This model carries a deletion of all five established Slco1a and 1b and two predicted Slco1a-like mouse genes as well as a random transgenic insertion of human SLCO1B1 (OATP1B1) under control of liver specific ApoE promoter.
  • Contains a cre-mediated deletion of the following established genes in the Slco1a/1b cluster: Slco1a1, Slco1a4, Slco1a5, Slco1a6, and Slco1b2.
  • SLCO1B1 (OATP1B1) is an important hepatic uptake transporter that can transport a wide variety of drugs, such as many statins.
  • Useful in dissecting the role of human OATP1B1 in hepatic liver uptake, drug-drug interaction and drug toxicity.
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse
Strain Type:Congenic
Allele Type:Constitutive Knockout;Random Transgenic;Genetically Humanized
Coat Color:Albino
Genetic Background:FVB

Other Genetic Notes:

Wildtype for Nnt mutation; carries Pde6brd1 mutation

Guides & Publications

Initial Publication: 

  • van de Steeg E, van Esch A, Wagenaar E, Kenworthy KE, Schinkel AH (2012). Influence of human OATP1B1, OATP1B3, and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic mice. Clin Cancer Res. 2012 Dec 14.
  • van de Steeg E, Stránecký V, Hartmannová H, Nosková L, Høebíèek M, Wagenaar E, van Esch A, de Waart DR, Oude Elferink RP, Kenworthy KE, Sticová E, Al-Edreesi M, Knisely AS, Kmoch S, Jirsa M, Schinkel AH (2012). Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J. Clin. Invest. 122 (2) 519-28.

Applications & Therapeutic Areas

  • ADMET
  • Metabolic Disease
  • Safety Assessment

Transit, Housing & Welfare

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Contract Services

mouse

Humanized OATP1B1 Mouse

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.

Pricing - USD

10708

ItemCommercialNonprofit
Cryopreserved Model$34,650.00$26,250.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - EUR

10708

ItemCommercialNonprofit
Cryopreserved Model€26.250,00€22.050,00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

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