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Abb/B2m
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- Overview
- Genetics
- Guides & Publications
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Overview
Nomenclature: B6.129-H2-Ab1tm1Gru B2mtm1Jae N17
- Contains a disruption of the H2-Ab1 gene
- Expresses no A or E MHC class II molecules and therefore lacks most CD4+ T cells
- Useful in transplantation, gene therapy and immunological disease research
Origin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication: Grusby MJ, Auchincloss H Jr, Lee R, Johnson RS, Spencer JP, Zijlstra M, Jaenisch R, Papaioannou VE, Glimcher LH. (1993) Mice lacking major histocompatibility complex class I and class II molecules. Proc Natl Acad Sci USA, 90(9):3913-3917.
Applications & Therapeutic Areas
- Immunology
- Inflammation
Transit, Housing & Welfare
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Diet
- Pricing
- Licensing
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Abb/B2m
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
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