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Tbet Knockout (C57BL/6)

Constitutive Knockout

Tbet Knockout (C57BL/6)
EZcohort® Models
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This model is available for immediate cryorecovery.

  • Model #
  • Genotype
  • Nomenclature
  • 3427
    B6.129S6-Tbx21tm1Glm N10
  • Altered cytokine production and differentiation of T helper cells
  • Decreased NK cell function
  • Immune system hypersensitivity makes this an excellent model of asthma"

Genetic Background:

C57BL/6

Origin:

The T-bet model was developed by Laurie H. Glimcher at Harvard University.  The model was creeated by targeting the Tbx21 gene in TC-1 ES cells and injecting the targeted cells into blastocysts.  Resultant chimeras were backcrossed to C57BL/6J for nine generations.  Taconic received stock in 2004.  The line was backcrossed to C57BL/6JBom for embryo transfer derivation (N10).  The colony was maintained through incrossing homozygous mice.


Color:

Black

Species:

Mouse


To purchase this EZcohort model, sign the terms of sale (choose from the list below) and email it directly to info@taconic.com with a purchase order for the purchase price:

This model is sold under terms which grant perpetual use rights.