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Rdh16 - Model 10540 - KO

Constitutive Knockout

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 10540
    C57BL/6-Rdh16tm1.2 mrl
  • The targeting vector has been generated using C57BL/6J DNA and transfected into TaconicArtemis C57BL/6NTac ES cell line.
  • Exon 1 contains the translation initiation codon.
  • Exon 2 has been flanked by loxP sites (size of loxP-flanked region: 1.4 kb).
  • The constitutive KO allele has been generated after Cre-mediated recombination by crossing chimeras to a Cre-Deleter on a C57BL/6 background.
  • The constitutive KO line has been derived using C57BL/6NTac animals and the Cre-transgene was removed by segregation.
  • Deletion of exon 2 should result in loss of function of the Rdh16 gene by deleting part of the catalytic domain and by generating a frameshift from exon 1 to exon 3 (premature Stop codon in exon 3).
  • According to NCBI and Ensembl databases, there are 2 genes in the neighborhood of the Rdh16 gene:

    • The Rdh9 gene (ENSMUSG00000056148) is located approx. 18 kb upstream of Rdh16 exon 2 in a tail-to-head orientation.
    • The Rdh18 gene (ENSMUSG00000054031) is located approx. 13 kb downstream of Rdh16 exon 2 in a head-to-tail orientation.

  • Datamining and Design performed in 2009.

Gene Family:


Genetic Background:


Gene Symbol:


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Allele Type:





Cryopreserved at Taconic



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GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

  • A minimum of four (4) mice mutant for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 mutant mice.
  • Validated genotyping protocols
  • Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO. The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.