GSTP1/2 Double Knockout Mouse

Genetic Background:

C57BL/6

Origin:

The Gstp1/2 double knockout was developed in the laboratory of C. Roland Wolf at the Imperial Cancer Research Fund Molecular Pharmacology Unit, Dundee, United Kingdom. A Gstp1/2 targeting vector, replacing all of the Gstp1 gene and exons 6 and 7 of the Gstp2 gene with a resistance cassette, was transfected into E14Tg2a.IV ES cells. Properly targeted ES cells containing a homologous recombination event were selected, cloned, and injected into blastocysts. Chimeric mice were mated with MF1 mice to generate mice heterozygous for GSTP1/2 knockout. Heterozygous mice were interbred to generate mice homozygous for GSTP1/2 knockout. Founder lines were backcrossed to C57BL/6. Taconic received embryos from CRT in 2015.

Source:

Cancer Research Technology (CRT)

Species:

Mouse

Initial Publication:

Henderson CJ et al. 1998. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proceedings of the National Academy of Sciences USA. 95:5275-80.

To purchase this EZcohort model, sign the Terms of Sale (choose from the list below) and email it directly to legal@taconic.com:

This model is sold under terms which grant perpetual use rights.