Flp Deleter

Random Transgenic

Flp Deleter Random Transgenic Mouse Model

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 7089-F
    tg/wt
    C57BL/6-Tg(CAG-Flpe)2Arte
  • 7089-M
    tg/wt
    C57BL/6-Tg(CAG-Flpe)2Arte
  • 7089-F
    tg/tg
    C57BL/6-Tg(CAG-Flpe)2Arte
  • 7089-M
    tg/tg
    C57BL/6-Tg(CAG-Flpe)2Arte
  • Ubiquitously active general Flp deleter.
  • In vitro-derived Flp recombinase under the control of the chicken beta-actin promoter and an hCMV immediate early enhancer. The use of the chimeric CMV enhancer/beta-actin promoter leads to a ubiquitous expression profile in eukaryotes. The Flp recombinase carries a minimal, nuclear localization signal from the SV40 larger T-antigen. Additional elements of the expression cassette are an intron with splice donor and acceptor sites upstream of the Flp gene and a synthetic polyadenylation signal downstream of the Flp.
  • This colony is currently being intracrossed to homozygosity. In the interim, mice may be sold as carriers. Mice with a genotype of Carrier(C) carry the transgene, but may be either hemizygous or homozygous.
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Genetic Background:

C57BL/6 Background

Origin:

The Flp Deleter mouse was developed by Artemis Pharmaceuticals (now Taconic). The mutation was introduced through random integration (microinjection) of the CAGGS-Flpe into C57BL/6 zygotes. The line was backcrossed 10 generations to C57BL/6NTac and intercrossed to homozygosity. The line was rederived in 2013 and is currently being intracrossed to homozygosity.

Color:

Black

Species:

Mouse


Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions of Sale and the following terms of use:
  • Access to this model requires execution of a Flp Deleter Research Breeding or Cross-breeding Agreement. Once the agreement is executed, you may order mice for use in breeding or cross-breeding. Please contact Taconic Customer Service for details.
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
  • Title to these Models and biological materials derived from them remains with Taconic Biosciences, Inc.
  • The Models will be used for research purposes only.
  • Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Conditions of Use - Printable Version