Floxed Jagged1 Mouse

Genetic Background:

129;C57BL/6

Origin:

The Jagged 1 conditional knockout was developed in the laboratory of Julian Lewis at the London Research Institute. A Jagged 1 targeting vector, containing a loxP flanked resistance cassette before exon 4 and a loxP site inserted after exon 5, was transfected into 129 ES cells. Properly targeted ES cells were transfected with a Cre expression vector to excise the resistance cassette, and injected into a C57BL6 blastocyst. Chimeric offspring were mated on a C57BL6 background. Taconic received embryos from CRT in 2015.

Source:

Cancer Research Technology (CRT)

Species:

Mouse

Initial Publication:

Brooker et al. 2006. Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development. 133:1277-86.

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