Data below based on a paper co-authored by scientists at the University of Pennsylvania
NOG-EXL vs NSG-SGM3: See Why Taconic Delivers Superior Results
Discover how NOG-EXL mice are outperforming the NSG-SGM3 mouse and similar models - more accurately replicating human immune cell composition, supporting functional development of key immune cells, and offering significantly improved survival with a more physiological, low-inflammatory cytokine profile.
Study Results Show Taconic’s NOG-EXL Mice Outperform the NSG-SGM3 Mouse
| NOG-EXL Mice | NSG-SGM3 Mice | |
|---|---|---|
| Genetic Background | NOD | NOD |
| High efficiency Human Immune Cell Engraftment | ||
| Enhanced Myeloid Cell Support | ||
| Clinically Relevant Cytokine Expression (Physiological, low-inflammatory) | ||
| Present and functional Plasmacytoid Dendritic Cells | ||
| Longer-term Survival Rate | Reduced due to cytokine toxicity | |
| Supports T Cell Development | ||
| Supports B Cell Development | ||
| Excellent for Humanized Immune System studies in Oncology & Immunology | Yes, offering broader utility | Widely used, but with limitations |
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What Is the Best Humanized Mouse Model for My Cancer Research?
The best humanized mouse model for cancer research depends on the specific experimental goals, such as tumor engraftment, immunotherapy response, or studying immune-tumor interactions. Below are some of the top humanized immune system (HIS) mouse models used in preclinical cancer research.
CIEA NOG Mouse®
Best for Humanization & Tumor Engraftment
Best for: Xenograft (CDX/PDX) tumor studies, immuno-oncology, and drug screening
- Super immunodeficient (lacking T, B, and NK cells)
- Superior engraftment of human tumor cells (CDX/PDX models)
- Suitable for checkpoint inhibitor & CAR-T therapy evaluation
B2m-NOG Mouse
Optimized for Longer Study Windows with Delayed GvHD
Best for: PBMC-based immunotherapy studies, including T cell-engaging therapies
- Lacks MHC Class I antigen presentation, reducing Graft vs Host Disease
- Allows longer-term immune cell engraftment (8+ weeks) vs. standard NOG mice
- Ideal for studying tumor-immune interactions in immunotherapy research
NOG-EXL (hGM-CSF/hIL-3 NOG) Mouse
Best for Myeloid Cell Studies & Leukemia Models
Best for: Myeloid-driven cancers (AML, lymphoma) & immuno-oncology studies
- Expresses human GM-CSF & IL-3, supporting human myeloid cell engraftment
- Superior for leukemia (AML) PDX models & macrophage/TAM-related studies
hIL-15 NOG Mouse
Best for NK Cell-Based Therapies & Immuno-Oncology
Best for: CAR-NK therapy, NK cell persistence studies, and tumor-immune system interactions
- Supports human NK cell development, improving efficacy testing of NK-based therapies
- Useful for studying tumor microenvironment modulation
Humanized PBMC NOG Mice
Best for Immuno-Oncology & Drug Response Studies
Best for: Checkpoint inhibitors, T cell therapies, CAR-T research
- PBMC-humanized mice enable studies of T cell responses to tumors, aiding immunotherapy development.
- PBMC-humanized mice are used to evaluate checkpoint inhibitors and CAR-T therapies by testing cancer treatments within a humanized immune system.
Introducing Flow Cytometry Solutions
At Taconic, we offer advanced flow cytometry services utilizing both conventional and spectral instrumentation. With extensive experience in creating and immunophenotyping mouse models and their base strains, our deep understanding and expertise ensure high-quality and reliable results.
Easy Access to Humanized Immune System Mice
The most robust and translatable rodent models available for immuno-oncology research, designed to recapitulate important aspects of the human immune system. Start projects sooner with off-the-shelf inventory available within days, not months.
huSelect™ Customized Humanization Options
Humanized immune system (HIS) mice are critical tools for in vivo evaluation of biological therapeutic target efficacy. HIS mice require a human donor source of CD34+ hematopoietic stem cells (HSCs), but genetic variance across donors can lead to inconsistent outcomes.
Taconic has developed a suite of offerings to address the issue of donor-to-donor variability by utilizing our extensive and well-characterized CD34+HSC inventory and expertise in immune cell characterization. Suitable for use in any of our CD34+ humanized immune system models (huNOG-EXL, FcResolv® huNOG-EXL, huNOG, FcResolv® NOG) or in a model of your choice.
huSelect™ Service* | Description |
| Select CD34+ HSC donors based on one or more HLA criteria | Our extensive CD34+ HSC donor catalog supports a wide range of HLA types for to suit your study parameters. |
| Request a specific CD34+ HSC donor | Repeat studies using CD34+ donors from prior orders |
| Reserve CD34+ cells for future use | Ensure an ongoing supply of CD34+ cells from selected donors |
| Pre-characterized CD34+ HSC donors | A number of donors have been validated in huNOG-EXL mice and pre-characterized for human immune cell populations for four timepoints out to 30 weeks post-engraftment. Data available upon request. |
| On-demand analysis of immune cell characterization | Flow cytometry services for immune cell analysis of models prior to shipping or for customer-provided samples. A variety of panels are available. |
*All service options are subject to availability. Other restrictions may apply.
Manage your research, not your vendors
Select any live or cryopreserved Taconic model, and let our expert Scientific Team manage your project. Our commitment to responsibility and transparency while managing customer resources enables total project stewardship while building lasting relationships and trust.
Featured NOG Mice Resources for Oncology and Immuno-Oncology Research
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