Rensselaer, NY — June 8, 2026 - Taconic Biosciences, a global leader in genetically engineered rodent models and services, today announced the launch of the hG-CSF KI NOG® mouse, a novel humanized immune system model designed to support the study of human neutrophil biology and neutrophil-targeted therapies.
Neutrophils play essential roles in inflammation, infectious disease, cancer, and immune regulation, yet studying human neutrophil responses in vivo has remained challenging. While several humanized mouse models express human granulocyte colony-stimulating factor (G-CSF), these models often retain murine G-CSF signaling, resulting in stimulation of both human and mouse neutrophils.
The hG-CSF KI NOG mouse addresses this challenge through a unique genetic design. Human G-CSF is knocked into the endogenous mouse G-CSF receptor locus, disrupting murine G-CSF signaling while enabling human G-CSF expression. Following engraftment with human CD34+ hematopoietic stem cells, researchers can selectively stimulate human neutrophils while reducing confounding effects of concurrent mouse neutrophil activation.
“Human neutrophils are increasingly recognized as key drivers of disease biology and therapeutic response across multiple research areas,” said Monika Buczek, PhD, Portfolio Manager at Taconic Biosciences. “The hG-CSF KI NOG mouse provides researchers with a unique tool to specifically investigate human neutrophil function in vivo, helping generate more translationally relevant insights for drug discovery and development.”
