About the White Paper:
While an exceptional number of genetically engineered mouse and rat models already exist, it is often still the case that design and production of a new custom-generated model can prove advantageous. Developing custom models through transgenesis is often thought to be a relatively simple and fast approach.
Transgenes can be introduced into the mouse genome in either a random or targeted manner to generate transgenic mice, and each strategy has long been used to develop mouse models that express foreign gene products in a desirable or advantageous manner. Many different factors may impact the success of a new transgenic model generation project. Two important factors which may arise, depending on the model design, are the choice of promoter and the choice of safe harbor site.
This white paper provides guidance in selecting the right promoter and safe harbor site for your custom-generated transgenic mouse model. Taconic model generation experts explore the background associated with each choice, as well as basic options for a safe harbor site, to provide a starting point to those considering the generation of a new transgenic model.
