TACONIC BIOSCIENCES®
Genetically Engineered Animal Models

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Genetically Engineered Animal Models

Design precise, translatable, genetically-engineered animal models for preclinical research and drug discovery.

Taconic Biosciences' globally-recognized scientific project managers support your custom model design project from design to delivery:

  • PhD Scientific Program Managers individually supervise each project to support your research goals.
  • Taconic's geneticists, embryologists, molecular biologists, and preclinical scientists are on hand to consult on each stage of the process.
  • Taconic's extensive experience in outsourced, in vivo project management assures on-time, on-budget delivery of your animal model.
Developing the Right Model to Deliver the Right Results:

  • Multiple genetic modification platforms provide flexibility: CRISPR, ES Cell, Pronuclear Injection
  • Fully licensed provider of model generation services, one of few companies in the world licensed to work on rats and mice, prokaryotic and eukaryotic cells
  • Comprehensive, high-throughput platforms for qualitative and quantitative genotyping & profiling
  • Capacity to produce animals at five health standards including Germ Free for microbiota studies
  • Embryology capabilities for RapidEXPANSION™ result in up to four-fold reduction in breeding timelines
  • Over 4000 models generated in last 10 years
  • Twenty years of experience
All animal operations are overseen by board-certified veterinarians and the standing Institutional Animal Care and Use Committee (IACUC).

Page Contents:

Genetic Modification & Design

Taconic is the most experienced rodent model design company in the industry, with a sixty-five year record of consistent quality and innovation.

Each custom model design project develops along an agile framework, letting you reassess and retarget your model fluidly as new data becomes available. You can pause or postpone projects at any time, or even "back up" project milestones via cryopreservation.

Knockout Mouse Generation

Gain critical insights into basic gene function and explore pathogenesis and drug development with conditional and constitutive knockout mice.

Knock-In Mouse Generation

Taconic designs, breeds, and validates knock-in mouse models for translational research, enabling researchers to analyze gene expression, identify regulatory elements, and model disease in humanized mice.

Taconic has successfully completed over 315 genetic humanization projects within the last ten years.

Transgenic Mouse Models

Design and generate study-ready cohorts of transgenic mice to study transgene expression and function in specific physiological processes.

Targeted, conditional, and random transgene expression options available.

Knockdown Mice Generation

Gain precise control over in vivo gene expression in knockdown mice with RNA interference and inducible/reversible miRNA expression.

Taconic was the first company to commercialize in vivo knockdown, in 2007, and has more institutional experience with knockdown mouse generation than any comparable vendor.

Genome Editing Technology

Taconic is a fully-licensed provider of genetically-engineered animal model generation services, able to partner with you at any stage of the model design process.

CRISPR Gene Editing

Use the latest CRISPR/Cas9 gene editing technology to generate precise, translatable research models with a 100% success rate.

Taconic Biosciences was the first vendor to utilize CRISPR in both mice and rats, and is the first commercial custom animal model developer to hold licenses from both the Broad Institute and the UC Berkeley. In 2017, Taconic licensed additional CRISPR technologies from ERS Genomics to complement Taconic's existing Broad License.

Rapid Cohort Expansion

Taconic's exclusive ExpressMODEL® cohort expansion program saves months off of overall project timelines, taking your genetic modification from vector construction to a homozygous cohort in as little as fifty four weeks.

Licensing

Licensing and usage rights for Taconic's genetically engineered animal models are adjusted to the needs of your institution.

Research Applications

Learn how the ability to design targeted animal models can accelerate project timelines in your area of application.

Humanizing the Mouse Genome: Generating New Tools for Preclinical ResearchDownload the Taconic Biosciences' Poster:
In this poster, we will present examples of genetic humanization projects and discuss the pros and cons of the most common strategies: BAC transgenesis, minigene insertion, and full gene replacement. We will present the success rate derived from the analysis and of over 100 independent genetic humanization projects using the two most common approaches, namely gene replacement and minigene insertion, and provide specific guidelines for generation of these preclinical models.
Related White Papers Download the Taconic Biosciences' White Papers:
Genetically Engineered Model Publications Database Search Taconic's Model Generation Solutions database by application or model type:

Model Generation Solutions inquiry Talk to a Taconic Biosciences scientist about designing a custom model:
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