White Paper

Genetically Engineered Models for Advanced Syngeneic Tumor Modeling

About the White Paper:

Genetically engineered models (GEMs) can increase the flexibility and feasibility of performing advanced syngeneic tumor studies.

However, there are multiple types of models available such as knockouts (KOs), transgenics, and humanized knock-ins (KIs). Depending on your research goals, one specific model might be better suited than another. While standard inbred strains are commonly used, GEMs confer many benefits to syngeneic studies by enabling researchers to use human-specific therapeutics, circumvent species-specific differences, and understand the role of the immune system in the elimination of tumors. 

This white paper examines the GEMs available for syngeneic studies and highlights the benefits of each.

Read this white paper to learn:

  • The benefits of advanced preclinical models in immuno-oncology research
  • Which GEMs are most commonly utilized in syngeneic research studies
  • How to select the most appropriate tumor model system in which to evaluate immuno-oncology therapeutics

Why Taconic?

Taconic Biosciences is a global leader in genetically engineered mouse models and colony management services. We support researchers in advancing their science with innovative, reliable solutions. Learn More about our Fully Integrated Custom Model Generation and Colony Management Solutions.

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Meet the Authors

Caroline Mitchell

Caroline Mitchell, PhD LinkedIn

Caroline Horizny Mitchell, PhD has experience in molecular biology research, creating compelling scientific content, and developing marketing strategies. Caroline has experience in scientific writing, content creation, and RNA biology and nanotechnology. She obtained her B.S. and M.S. in biology from Rensselaer Polytechnic Institute and Ph.D. in Nanoscale Science from the University at Albany.

Philip Dube

Philip Dubé, PhD LinkedIn

Director, Global Application Sciences

Philip Dubé, PhD has special expertise in rodent models of inflammatory bowel disease (IBD) and has 18+ years’ experience in rodent model use. He is the Director of Global Application Sciences at Taconic. He completed research fellowships at Vanderbilt University and Children’s Hospital Los Angeles, and served as an Institutional Animal Care and Use Committee member. He holds a Ph.D. in physiology and an Honor’s B.Sc. in pharmacology from the University of Toronto.