Males exhibit average systolic blood pressures greater than 200 mmHg by 3-4 months of age
The SHR is generally used for studies in hypertension and cardiovascular research
Based on historical usage, the SHR has outbred nomenclature NTac:SHR. However, genetic testing has shown that this colony is homozygous at all alleles tested (inbred). Taconic maintains the SHR through random breeding in a closed colony.
Origin:
The Spontaneously Hypertensive outbred model was developed by NIH in 1966 from Wistar Kyoto outbred stock from Okamoto, Kyoto School of Medicine. Taconic received stock at F35 from the NIH Animal Genetic Resource in 1972. The rats were derived by embryo transfer in 1984.
n= 200 per sex at the MPF health standard from US colonies. Data collected 2008-12.
High and Low represent mean +/- 2 standard deviations. Based on sample size the charts above represents ~95% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves.
Growth charts are provided only as a guide, if a specific weight criteria is needed please order animals by weight.
Customize this chart by clicking the legend elements, then explore download options by hovering your cursor over the down arrow to the right of the chart title.
