Author(s) |
(Date) |
Paper Title |
Citation |
Model Type |
Applications |
Full Text |
| Mejdrová I, et al. Mouse over for full list |
(2023) | Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure. | J Med Chem 66(4):2422-2456 | |||
| Skoda J, et al. Mouse over for full list |
(2022) | Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice. | Biochem Pharmacol 197:114905 | |||
| Ly JQ, et al. Mouse over for full list |
(2021) | Investigating the Utility of Humanized Pregnane X Receptor-Constitutive Androstane Receptor-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction. | Drug Metab Dispos 49(7):540-547 | |||
| Skoda J, et al. Mouse over for full list |
(2020) | Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain. | Cells 9(12) | |||
| Crosby M, et al. Mouse over for full list |
(2019) | Suppression of Hepatic CYP3A4 Expression and Activity by 3-Methylcholanthrene in Humanized PXR-CAR-CYP3A4/3A7 Mice. | Drug Metab Dispos 47(3):279-282 | |||
| Zhao Y, et al. Mouse over for full list |
(2018) | Significantly Improved Pharmacokinetics Enhances In Vivo Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis. | Antimicrob Agents Chemother 62(10) | |||
| MacLeod AK, et al. Mouse over for full list |
(2018) | Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy. | Clin Cancer Res 24(9):2138-2147 | |||
| MacLeod AK, et al. Mouse over for full list |
(2015) | Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models. | Cancer Res 75(21):4573-81 | |||
| Choo EF, et al. Mouse over for full list |
(2015) | Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor. | Drug Metab Dispos 43(6):864-9 | |||
| Ly JQ, et al. Mouse over for full list |
(2017) | Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions. | Mol. Pharm. 14(5):1754-1759 | Humanization |
Tox & Safety Assessment | |
| Scheer N, et al. Mouse over for full list |
(2008) | A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. | J. Clin. Invest. 118(9):3228-39 | |||
| Scheer N, et al. Mouse over for full list |
(2010) | In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice. | Drug Metab. Dispos. 38(7):1046-53 | |||
| Ross J, et al. Mouse over for full list |
(2010) | Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo. | Toxicol. Sci. 116(2):452-66 | |||
| Hasegawa M, et al. Mouse over for full list |
(2011) | Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line. | Mol. Pharmacol. 80(3):518-28 |
Welcome! Tell us a little about yourself