Humanized PXR-CAR-CYP3A4/3A7 Mouse Publications

Humanized PXR-CAR-CYP3A4/3A7 Mouse Model Page

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Scheer N, et al.
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Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, Wolf CR
(2008) A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J. Clin. Invest. 118(9):3228-39
Scheer N, et al.
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Scheer N, Ross J, Kapelyukh Y, Rode A, Wolf CR
(2010) In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice. Drug Metab. Dispos. 38(7):1046-53
Ross J, et al.
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Ross J, Plummer SM, Rode A, Scheer N, Bower CC, Vogel O, Henderson CJ, Wolf CR, Elcombe CR
(2010) Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo. Toxicol. Sci. 116(2):452-66
Hasegawa M, et al.
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Hasegawa M, Kapelyukh Y, Tahara H, Seibler J, Rode A, Krueger S, Lee DN, Wolf CR, Scheer N
(2011) Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line. Mol. Pharmacol. 80(3):518-28