Spontaneously Hypertensive

Spontaneously Hypertensive Outbred Rat Model
  • Cryopreserved
  • Rat
  • Albino
  • Available for direct purchase by CRO
Model No.NomenclatureGenotype
SHRNTac:SHR
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Overview

Nomenclature: NTac:SHR

  • Derived from the Okamoto-Aoki Strain
  • Males exhibit average systolic blood pressures greater than 200 mmHg by 3-4 months of age
  • The SHR is generally used for studies in hypertension and cardiovascular research
  • Based on historical usage, the SHR has outbred nomenclature NTac:SHR. However, genetic testing has shown that this colony is homozygous at all alleles tested (inbred). Taconic maintains the SHR through random breeding in a closed colony.

Origin

The Spontaneously Hypertensive outbred model was developed by NIH in 1966 from Wistar Kyoto outbred stock from Okamoto, Kyoto School of Medicine. Taconic received stock at F35 from the NIH Animal Genetic Resource in 1972. The rats were derived by embryo transfer in 1984.

Genetics

Species:Rat
Strain Type:Outbred or Mixed
Coat Color:Albino
Coat Color Loci: Tyrc
Genetic Background:Other
Coat Color Loci: Tyrc

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Applications & Therapeutic Areas

  • Cardiovascular Disease

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Data

Average litter size: 7

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2024 Pricing Guide Now Available

Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.