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Tbet Knockout (BALB/c)
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Overview
Nomenclature: C.129S6(B6)-Tbx21tm1Glm N10
- Altered cytokine production and differentiation of T helper cells
- Decreased NK cell function
- Immune system hypersensitivity makes this an excellent model of asthma
Origin
The T-bet model was developed by Laurie H. Glimcher at Harvard University. The model was creeated by targeting the Tbx21 gene in TC-1 ES cells and injecting the targeted cells into blastocysts. Resultant chimeras were backcrossed to C57BL/6J for one generation and then backcrossed to BALB/cJ for nine generations.. Taconic received stock in 2004. The line was backcrossed to BALB/cJBom for embryo transfer derivation (N10). The colony was maintained through incrossing homozygous mice.
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
Taconic’s Colony Management experts can design a plan to grow your colony faster.
Genetics
Guides & Publications
Applications & Therapeutic Areas
- Inflammatory Bowel Disease
Transit, Housing & Welfare
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Diet
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Tbet Knockout (BALB/c)
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
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