Sort1 - Model 10720 - TTG

  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
10720C57BL/6-Gt(ROSA)26Sortm1 mrl
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Overview

Nomenclature: C57BL/6-Gt(ROSA)26Sortm1 mrl

  • The targeting vector has been transfected into the TaconicArtemis C57BL/6NTac ES cell line.
  • The following elements have been inserted into the ROSA26 locus:

    • A CAG promoter cassette (containing a cytomegalovirus early enhancer element, a chicken beta-actin promoter and an adenovirus intron).
    • The Sort1 open reading frame (based on NCBI transcript NM_019972_2).
    • A synthetic polyadenylation signal.
    • A Neomycin resistance (NeoR) cassette containing a polyadenylation signal and lacking a translation initiation codon.

  • The constitutive TTG line has been generated by crossing chimeras to C57BL/6NTac animals.
  • The SORT1 protein is expressed under the control of the CAG promoter.
  • The presence of the NeoR cassette terminates the transcription from the ROSA26 promoter.
  • Line has poor viability and reproductivity.
  • Datamining and Design performed in 2009.

Availability

Cryopreserved at Taconic

Source: TaconicArtemis

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

Taconic’s Colony Management experts can design a plan to grow your colony faster.

Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Targeted Transgenic
Genetic Background:C57BL/6
Gene Family: Sortilin
Gene Symbol: Sort1
Gene Accession Number:  NM_019972.2
Gene Name: sortilin 1

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Guides & Publications

Transit, Housing & Welfare

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Sort1 - Model 10720 - TTG

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

    ItemCommercialNonprofit
    Cryopreserved Model$32,500$5,500
      ItemCommercialNonprofit
      Cryopreserved Model€29.500€5.005

       

      Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

      Fees for Taconic Transit Cages™ and freight are in addition to the price above.

       

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