Sds - Model 10998 - KO

  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
10998C57BL/6-Sdstm1.2 mrl
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Overview

Nomenclature: C57BL/6-Sdstm1.2 mrl

  • The targeting vector has been generated using C57BL/6J DNA and transfected into TaconicArtemis C57BL/6NTac ES cell line.
  • Exon 2 contains the translation initiation codon.
  • Exons 3 to 6 have been flanked by loxP sites (size of loxP-flanked region: 2.5 kb).
  • The constitutive KO allele has been generated after Cre-mediated recombination by crossing chimeras to a Cre-Deleter on a C57BL/6 background.
  • The constitutive KO line has been derived using C57BL/6NTac animals and the Cre-transgene was removed by segregation.
  • Deletion of exons 3 to 6 should result in loss of function of the Sds gene by deleting part of the catalytic domain and by generating a frameshift from exon 2 to exons 7 and 8 (premature Stop codon in exon 7).
  • The remaining recombination sites are located in non-conserved regions of the genome.
  • According to NCBI and Ensembl databases, there are 2 genes in the neighborhood of the Sds gene:

    • the SdsI gene (Entrez ID: 257635; ENSMUSG00000029596) and is located approx. 7.5 kb upstream of Sds exon 3 in a head-to-head orientation.
    • the 1300012G16Rik gene (Entrez ID: 71772; ENSMUSG00000029598) is located approx. 1.5 kb downstream of Sds exon 6 in a tail-to-tail orientation.

  • Datamining and Design performed in 2009.

Availability

Cryopreserved at Taconic

Source: TaconicArtemis

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Constitutive Knockout
Genetic Background:C57BL/6
Gene Family: Dehydratase
Gene Symbol: Sds
Gene Accession Number:  NM_145565.1
Gene Name: serine dehydratase

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Sds - Model 10998 - KO

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

    ItemCommercialNonprofit
    Cryopreserved Model$32,500$5,500
      ItemCommercialNonprofit
      Cryopreserved Model€29.500€5.005

       

      Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

      Fees for Taconic Transit Cages™ and freight are in addition to the price above.

       

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