| Model No. | Nomenclature | Genotype |
|---|---|---|
| 12979 | C57BL/6-Rock2tm1.1(K121A)Mrl | Inquire for genotype |
Rock2 - Model 12979 - PM
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Overview
Nomenclature: C57BL/6-Rock2tm1.1(K121A)Mrl
- The targeting vector has been generated using C57BL/6J DNA and transfected into TaconicArtemis C57BL/6NTac ES cell line.
- Rock2 Exon 1 contains the translation initiation codon.
- The K121A point mutation has been introduced into Rock2 exon 4.
- The positive selection marker (Puromycin resistance - PuroR) has been flanked by FRT sites and inserted into intron 3.
- The constitutive PM allele has been generated after Flp-mediated recombination by crossing chimeras to a Flp-Deleter on a C57BL/6 background.
- The constitutive PM line has been derived using C57BL/6NTac animals and the Flp-transgene was removed by segregation.
- The remaining recombination site will be located in a non-conserved region of the genome.
- Datamining and Design performed in 2012.
Availability
Cryopreserved at TaconicSource: Merck Research Laboratories
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Rock2 - Model 12979 - PM
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
The GEM Collection Commercial and Academic/Non-Profit Terms of Sale grant perpetual use rights.
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USD
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $21,000 | $5,500 |
*If you choose to breed this model at Taconic, you are eligible for a 20% discount on the Commercial repository model price as outlined below.
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $16,800 | $5,500 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
EUR
| Item | Commercial | Nonprofit |
| Cryopreserved Model | €21.000 | €5.005 |
*If you choose to breed this model at Taconic, you are eligible for a 20% discount on the Commercial repository model price as outlined below.
| Item | Commercial (with 20% breeding discount) | Nonprofit |
| Cryopreserved Model | €16.800 | €5.005 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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