Nomenclature: B6.SJL-Ptprc^a/BoCrTac Rag2^tm1Fwa Tg(TcrH-Y)71Vbo N7

• Homozygous mice exhibit total inability to initiate V(D)J rearrangement and fail to generate mature T or B lymphocytes. Otherwise, the Rag2 mouse has apparently normal hematopoiesis.
• The H-Y transgene results in a large fraction of T cells expressing a T cell receptor specific for a minor histocompatibility antigen (H-Y) which is present on male but not female cells in the context of MHC Class I (H-2Db). On a B6.SJL background (H2Db), thymocytes are severely depleted in male HY mice but develop into CD8 single positive T cells in female HY mice. These mice carry an H2b haplotype which is a positive selecting background for conventional T cells. Therefore the male HY transgenic mice are severely depleted of thymocytes because of deletion due to recognition of HY/H-2Db but not female HY transgenic mice.
• These mice can be useful for studying mechanisms of self-tolerance and lineage commitment and the role of CD4 and CD 8 molecules in the deletion process of autospecific cells.

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