Rag2/HY - Model 467

Rag2 (Model 467) Constitutive Knockout / Random Transgenic Mouse Model
  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
467B6.SJL-Ptprca/BoCrTac Rag2tm1Fwa Tg(TcrH-Y)71Vbo N7
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Overview

Nomenclature: B6.SJL-Ptprca/BoCrTac Rag2tm1Fwa Tg(TcrH-Y)71Vbo N7

  • Homozygous mice exhibit total inability to initiate V(D)J rearrangement and fail to generate mature T or B lymphocytes. Otherwise, the Rag2 mouse has apparently normal hematopoiesis.
  • The H-Y transgene results in a large fraction of T cells expressing a T cell receptor specific for a minor histocompatibility antigen (H-Y) which is present on male but not female cells in the context of MHC Class I (H-2Db). On a B6.SJL background (H2Db), thymocytes are severely depleted in male HY mice but develop into CD8 single positive T cells in female HY mice. These mice carry an H2b haplotype which is a positive selecting background for conventional T cells. Therefore the male HY transgenic mice are severely depleted of thymocytes because of deletion due to recognition of HY/H-2Db but not female HY transgenic mice.
  • These mice can be useful for studying mechanisms of self-tolerance and lineage commitment and the role of CD4 and CD 8 molecules in the deletion process of autospecific cells.

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse
Strain Type:Congenic
Allele Type:Constitutive Knockout;Random Transgenic
Genetic Background:C57BL/6

Guides & Publications

Initial Publication: Schulz RJ, Parkes A, Mizoguchi E, Bhan AK, Koyasu S; (1996) Development of CD4-CD8- alpha beta TCR+NK1.1+ T lymphocytes: thymic selection by self antigen; Journal of Immunology Vol. 157(10) pp. 4379-4389.

Transit, Housing & Welfare

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Rag2/HY - Model 467

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.

Pricing - USD

467

ItemCommercialNonprofit
Cryopreserved Model$29,400.00$21,000.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - EUR

467

ItemCommercialNonprofit
Cryopreserved Model€26.250,00€19.425,00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

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