Pxr Knockout Mouse

Pxr Constitutive Knockout Mouse Model
  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
9100C57BL/6-Nr1i2tm3Arte
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Overview

Nomenclature: C57BL/6-Nr1i2tm3Arte

  • This targeted mutation strain carries a deletion of the mouse Nr1i2 gene which encodes for the nuclear receptor PXR.
  • Useful in defining the effect of PXR on CYP induction and therefore pharmacokinetics, drug toxicity, and efficacy.

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

Taconic’s Colony Management experts can design a plan to grow your colony faster.

Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Constitutive Knockout
Genetic Background:C57BL/6

Guides & Publications

Initial Publication: Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, Wolf CR. (2008) A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J. Clin. Invest. 118(9): 3228-3239.

Applications & Therapeutic Areas

  • ADMET

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Pxr Knockout Mouse

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.

Pricing - USD

9100

ItemCommercialNonprofit
Cryopreserved Model$23,100.00$17,325.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - EUR

9100

ItemCommercialNonprofit
Cryopreserved Model€21.000,00€15.855,00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

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2024 Pricing Guide Now Available

Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.