Prkg1 - Model 14146 - PM

  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
  • GEM Collection
Model No.NomenclatureGenotype
14146Inquire for genotypeInquire for genotype
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Overview

  • The targeting vector has been generated using C57BL/6J DNA and transfected into TaconicArtemis C57BL/6NTac ES cell line.
  • Exon 1 contains the translation initiation codon.
  • Both in frame Met in exon 1 have been mutated to translation termination codons (M1* and M13*).
  • The positive selection marker (Puromycin resistance - PuroR) has been flanked by FRT sites and inserted into intron 1.
  • The constitutive PM allele has been generated after Flp-mediated recombination by crossing chimeras to a Flp-Deleter on a C57BL/6 background.
  • The constitutive PM line has been derived using C57BL/6NTac animals and the Flp-transgene was removed by segregation. This KI-PM allele should only express the Prkg1 transcript NM_011160.3.
  • The remaining FRT recombination site will be located in a non-conserved region of the genome.
  • Datamining and Design performed in 2013.

Source: TaconicArtemis

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

Taconic’s Colony Management experts can design a plan to grow your colony faster.

Genetics

Species:Mouse
Strain Type:Outbred or Mixed
Allele Type:Point Mutation
Genetic Background:Mixed
Gene Family: Kinase
Gene Symbol: Prkg1
Gene Accession Number: ENSMUST00000073581
Gene Name: protein kinase, cGMP-dependent, type I

14146-prkg1.jpg

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Prkg1 - Model 14146 - PM

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

The GEM Collection Commercial and Academic/Non-Profit Terms of Sale grant perpetual use rights.

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USD

    ItemCommercialNonprofit
    Cryopreserved Model$21,000$5,500

     

    *If you choose to breed this model at Taconic, you are eligible for a 20% discount on the Commercial repository model price as outlined below.

    ItemCommercialNonprofit
    Cryopreserved Model$16,800$5,500

    Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

    Fees for Taconic Transit Cages™ and freight are in addition to the price above.

    EUR

    ItemCommercialNonprofit
    Cryopreserved Model€21.000€5.005

    *If you choose to breed this model at Taconic, you are eligible for a 20% discount on the Commercial repository model price as outlined below.

    ItemCommercial (with 20% breeding discount)Nonprofit
    Cryopreserved Model€16.800€5.005

    Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

    Fees for Taconic Transit Cages™ and freight are in addition to the price above.

     

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