Pla2g4 - Model 11269 - TG

  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
  • GEM Collection
Model No.NomenclatureGenotype
11269C57BL/6-Tg(Camk2a-PLA2G4A)9 MrlInquire for genotype
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Overview

Nomenclature: C57BL/6-Tg(Camk2a-PLA2G4A)9 Mrl

  • The transgenic construct contains 5´ the 8.5 kb mouse CaM-kinase II alpha chain (mCamk2a) promoter fragment, an 850 bp DNA fragment containing the human b-globin intron 2, and 2247bp ORF of human PLA2G4A cDNA (GenBank Acc# NM_024420), followed by 221bp of SV40 poly A sequence at the 3´ end in a pGL3 vector backbone (Promega).
  • A consensus KOZAK sequence has been added upstream of the starter ATG.
  • The plasmid backbone was removed and the transgenic construct was microinjected in C57BL/6 mice by pronuclear injection.
  • Putative transgenic founders were identified by genotyping and bred for germline transmission with C57BL/6 mice.
  • Heterozygous transgenic mice were identified by genotyping.
  • Line 11266, C57BL/6-Tg(Camk2a-PLA2G4A)31 Mrl, has the highest expression level of the transgene in the brain.
  • Line 11269, C57BL/6-Tg(Camk2a-PLA2G4A)9 Mrl, has the medium expression level of the transgene in the brain.
  • Datamining and Design performed in 2009.

Availability

Cryopreserved at Taconic

Source: Xenogen

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Random Transgenic
Genetic Background:C57BL/6
Gene Family: Phospholipase
Gene Symbol: Pla2g4
Gene Accession Number:  NM_008869
Gene Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)

11269tg-allele.png key-allele.jpg

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Transit, Housing & Welfare

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Pla2g4 - Model 11269 - TG

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

The GEM Collection Commercial and Academic/Non-Profit Terms of Sale grant perpetual use rights.

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USD

    ItemCommercialNonprofit
    Cryopreserved Model$21,000$5,500

     

    *If you choose to breed this model at Taconic, you are eligible for a 20% discount on the Commercial repository model price as outlined below.

    ItemCommercialNonprofit
    Cryopreserved Model$16,800$5,500

    Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

    Fees for Taconic Transit Cages™ and freight are in addition to the price above.

    EUR

    ItemCommercialNonprofit
    Cryopreserved Model€21.000€5.005

    *If you choose to breed this model at Taconic, you are eligible for a 20% discount on the Commercial repository model price as outlined below.

    ItemCommercial (with 20% breeding discount)Nonprofit
    Cryopreserved Model€16.800€5.005

    Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

    Fees for Taconic Transit Cages™ and freight are in addition to the price above.

     

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