Nod2 - Model 12910 - cTTG

  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
12910C57BL/6-Gt(ROSA)26Sor tm1(CAG-Nod2)Mrl
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Overview

Nomenclature: C57BL/6-Gt(ROSA)26Sor tm1(CAG-Nod2)Mrl

  • The targeting vector has been transfected into TaconicArtemis C57Bl/6 ES cell line.
  • The following elements have been inserted into the ROSA26 locus:

    • A CAG promoter cassette.
    • A loxP-flanked transcription termination cassette (STOP) containing a combination of polyadenylation signals.
    • The Nod2 ORF together with a Kozak sequence (GCCACC).
    • The hGH polyadenylation signal and an additional polyadenylation signal.

  • The conditional TTG line has been generated by crossing chimeras to C57BL/6NTac animals.
  • The constitutive TTG allele can be generated by Cre-mediated recombination by crossing line 12910 to a Cre-Deleter.
  • Deletion of the hGHpA cassette should result in transcription of the Nod2 cDNA.
  • The presence of the NeoR cassette will terminate the transcription from the ROSA26 promoter.
  • Datamining and Design performed in 2012.

Availability

Cryopreserved at Taconic

Source: TaconicArtemis

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

Taconic’s Colony Management experts can design a plan to grow your colony faster.

Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Conditional Targeted Transgenic
Genetic Background:C57BL/6
Gene Family: Caspase
Gene Symbol: Nod2
Gene Accession Number: NM_145857
Gene Name:  nucleotide-binding oligomerization domain containing 2

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Transit, Housing & Welfare

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Nod2 - Model 12910 - cTTG

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

    ItemCommercialNonprofit
    Cryopreserved Model$32,500$5,500
      ItemCommercialNonprofit
      Cryopreserved Model€29.500€5.005

       

      Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

      Fees for Taconic Transit Cages™ and freight are in addition to the price above.

       

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