Lclat1 - Model 10907 - cKO

  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
10907C57BL/6-Lclat1tm1.1mrl
View:
Select One

Overview

Nomenclature: C57BL/6-Lclat1tm1.1mrl

  • The targeting vector has been generated using C57BL/6J DNA and transfected into TaconicArtemis C57BL/6NTac ES cell line.
  • Exon 2 contains the translation initiation codon.
  • Exon 3 has been flanked by loxP sites (size of loxP-flanked region: 1.5 kb).
  • The conditional KO allele has been generated after Flp-mediated recombination by crossing chimeras to a Flp-Deleter on a C57BL/6 background.
  • The conditional KO line has been derived using C57BL/6NTac animals and the Flp-transgene was removed by segregation.
  • The constitutive KO allele can be generated by Cre-mediated recombination. Deletion of exon 3 should result in loss of function of the Lclat1 gene by deleting part of the catalytic domain and by generating a frameshift from exon 2 to all downstream exons (premature Stop codon in exon 4).
  • The remaining recombination sites are located in non-conserved regions of the genome.
  • Datamining and Design performed in 2009.

Availability

Cryopreserved at Taconic

Source: TaconicArtemis

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

Taconic’s Colony Management experts can design a plan to grow your colony faster.

Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Conditional Knockout
Genetic Background:C57BL/6
Gene Family: Transferase
Gene Symbol: Lclat1
Gene Accession Number: NM_001081071.1
Gene Name:  lysocardiolipin acyltransferase 1

10907wt-allele.png

10907cko-allele.png

10907ko-allele.png

key-allele.jpg

Guides & Publications

Transit, Housing & Welfare

Need more info? Click the live chat button or Contact Us

Lclat1 - Model 10907 - cKO

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

    ItemCommercialNonprofit
    Cryopreserved Model$32,500$5,500
      ItemCommercialNonprofit
      Cryopreserved Model€29.500€5.005

       

      Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

      Fees for Taconic Transit Cages™ and freight are in addition to the price above.

       

      Select my Health Standard

      Need help choosing the right Taconic Biosciences health standard for your research?

      Use the Health Standard Selector to enter your exclusion list. The tool will tell you which health standards meet your requirements.

      Get custom pricing guide

      2024 Pricing Guide Now Available

      Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.

      Looking for More Information

      Schedule A Scientific Consultation

      We provide you with coupled capabilities and service offerings, enabling your researchers to work with a single provider to meet their study needs while enjoying a more streamlined integrated process at any stage of a project.

      Speak with a Colony Management Specialist and Field Application Scientist that can help you develop and deploy the tailored solution you need.

      Want to Get in Touch?

      Chat with us or reach out to our global team

      phone

      2024 Pricing Guide Now Available

      Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.