Jak2 - Model 8235 - cKO

  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
8235C57BL/6-Jak2tm1.1 Mrl
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Overview

Nomenclature: C57BL/6-Jak2tm1.1 Mrl

  • The targeting vector has been generated using C57BL/6J DNA and transfected into C57BL/6NTac ES cell line.
  • Jak2 exon 3 contains the translation initiation codon.
  • Exon 20 has been flanked by loxP sites.
  • The conditional KO allele has been generated after Flp-mediated recombination by crossing chimeras to a Flp-Deleter on a C57BL/6 background.
  • The conditional KO line has been subsequently backcrossed to C57BL/6NTac animals for at least 2 generations and the Flp-transgene was removed by segregation.
  • The constitutive KO allele can be generated by Cre-mediated recombination.
  • Deletion of exon 20 should result in loss of function of the Jak2 gene by generating a frameshift (premature stop codon in exon 21).
  • The remaining recombination sites are located in intron regions of the genome.
  • Data mining and Design performed in 2006.

Source: Mouse Clinical Institute (MCI)

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Conditional Knockout
Genetic Background:C57BL/6
Gene Family: Kinase
Gene Accession Number: NM_001048177
Gene Name: Janus kinase 2

8235 WT

8235 cKO

0085 KO

key-allele.jpg

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Transit, Housing & Welfare

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Jak2 - Model 8235 - cKO

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

    ItemCommercialNonprofit
    Cryopreserved Model$32,500$5,500
      ItemCommercialNonprofit
      Cryopreserved Model€29.500€5.005

       

      Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

      Fees for Taconic Transit Cages™ and freight are in addition to the price above.

       

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