| Model No. | Nomenclature | Genotype |
|---|---|---|
| 12667 | B6.Cg -Hcsttm1.1dnax | Inquire for genotype |
Hcst - Model 12667 - KO
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Overview
Nomenclature: B6.Cg -Hcsttm1.1dnax
- The targeting vector has been generated using C57BL/6 DNA and transfected into C57BL/6 ES cell line.
- Hcst exons 3 and 4 were removed by the neomycin resistance cassette, which is flanked by loxP sites.
- The neomycin resistance gene has been deleted by transient transfection of Cre in targeted ES cells.
- Chimeric mice were produced and germ line transmission achieved.
- Deletion of exons 3 and 4 should result in loss of function of the Hcst gene by deleting critical domains for the expression of a functional protein.
- The remaining recombination sites are located in intron regions of the genome.
- See Hyka-Nouspikel & Phillips, Immunological reviews 214, 2006, for further details.
Availability
Cryopreserved at TaconicSource: DNAX
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Hcst - Model 12667 - KO
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $32,500 | $5,500 |
| Item | Commercial | Nonprofit |
| Cryopreserved Model | €29.500 | €5.005 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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