Model No. | Nomenclature | Genotype |
---|---|---|
4217 | B6.129P2-H2-Dbtm1 N12 | Inquire for genotype |
Nomenclature: B6.129P2-H2-Dbtm1 N12
H-2 Class I molecules are trimeric complexes assembled in the ER and formed by the association of a 42-kDa heavy chain, b2 microglobulin and a short (8-11 AA) peptide. Although there is a profound reduction of H-2 Class I molecules in the b2m targeted mutation mouse, there is still residual expression of functional H2-Db molecules. In contrast, no H2-Db molecules can be detected by indirect immunofluorescence analysis of peripheral T lymphocytes from the H2-Db-/- mouse. A compensatory increase in cell surface expression of other class I molecules was observed resulting in almost unaltered levels of cell surface expression of b2m. This increase cannot be attributed solely to enhanced expression of Q7 or Q9 (the most abundant Class Ib molecules at the surface of T lymphocytes) or to H2-Kb implying that there may be increased cell surface expression of other, unidentified class Ib molecules. This mouse model is a useful tool for evaluating the immunological potential of individual MHC class I molecules and for studying cytolytic T cell education as well as the role of Class Ib molecules.
Origin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 12 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Item | Commercial | Nonprofit |
---|---|---|
Cryopreserved Model | $21,000.00 | $13,000.00 |
If you choose to breed this model at Taconic, you are eligible for a 20% discount on the model price as outlined below.
Item | Commercial (with 20% breeding discount) | Nonprofit |
Cryopreserved Model | $/€16,800 | $/€10,400 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Item | Commercial | Nonprofit |
---|---|---|
Cryopreserved Model | €21.000,00 | €13.000,00 |
If you choose to breed this model at Taconic, you are eligible for a 20% discount on the model price as outlined below.
Item | Commercial (with 20% breeding discount) | Nonprofit |
Cryopreserved Model | $/€16,800 | $/€10,400 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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