| Model No. | Nomenclature | Genotype |
|---|---|---|
| 24386 | C57BL/6NTac–Glp1rtm10021Tac | Inquire for genotype |
Glp1r Conditional Knockout (cKO)
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- Description
- Price & Licensing
- Overview
- Genetics
- Applications & Therapeutic Areas
- Transit, Housing & Welfare
Overview
Nomenclature: C57BL/6NTac–Glp1rtm10021Tac
The model is a conditional knockout (cKO) of the Glp1r gene (glucagon-like peptide 1 receptor).
The Glp1r cKO mouse was developed by Taconic in 2026. This model was generated via conditional Knockout (KO) of the Glp1r gene. Exon 1 contains the translation initiation codon. Exon 2 was flanked by loxP sites (size of loxP-flanked region is 1.0 kb). The positive selection marker (Puromycin resistance – PuroR) was flanked by FRT sites and inserted into intron 1. The PuroR cassette also contained a tamoxifen-inducible Flpo recombinase (FlpoERT2-PuroR). The targeting vector was generated using BAC clones from the C57BL/6J RPCI-23 BAC library and was transfected into the Taconic Biosciences C57BL/6NTac ES cell line. Homologous recombinant clones were isolated using positive (PuroR) and negative (Thymidine kinase – Tk) selections. The conditional KO allele was obtained after Flp-mediated removal of the selection marker. The remaining recombination sites are located in non-conserved regions of the genome.
Availability
Cryopreserved at Taconic Biosciences
Origin
The Glp1r cKO mouse was developed by Taconic Biosciences.
Source
Taconic Biosciences
Genetics
Applications & Therapeutic Areas
- Metabolic Disease
- Obesity
Transit, Housing & Welfare
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- Pricing
- Licensing
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Glp1r Conditional Knockout
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
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