Gabrb2 - Model 6507 - KO

  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
6507B6;129S6-Gabrb2tm1.2 twr
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Overview

Nomenclature: B6;129S6-Gabrb2tm1.2 twr

  • The targeting vector has been generated using 129SvEv DNA and transfected into 129SvEv ES cell line.
  • Gabrb2 exons 6 and 7 were deleted by the neomycin resistance cassette, which is flanked by loxP sites.
  • Chimeric mice were produced and germ line transmission achieved.
  • The neomycin resistance gene has not been deleted in the constitutive KO mice.
  • Deletion of exons 6 and 7 should result in loss of function of the Gabrb2 gene by deleting functional domains of the protein.
  • Gabrb2 constitutive KO mice are in a mixed C57BL/6-129SvEv genetic background.
  • See C. Sur et al, The Journal of Neuroscience 21, 3409-3418, 2001, for further details.

Availability

Cryopreserved at Taconic

Source: Merck Research Laboratories

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse
Strain Type:Outbred or Mixed
Allele Type:Constitutive Knockout
Genetic Background:Mixed
Gene Family: Receptor
Gene Symbol: Gabrb2
Gene Accession Number: NM_008070
Gene Name:  gamma-aminobutyric acid (GABA) A receptor, subunit beta 2

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Gabrb2 - Model 6507 - KO

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

    ItemCommercialNonprofit
    Cryopreserved Model$32,500$5,500
      ItemCommercialNonprofit
      Cryopreserved Model€29.500€5.005

       

      Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

      Fees for Taconic Transit Cages™ and freight are in addition to the price above.

       

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