Gabra1 - Model 7088 - PM

  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
7088C57BL/6-Gabra1tm1.1(H101R)Rmck>
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Overview

Nomenclature: C57BL/6-Gabra1tm1.1(H101R)Rmck>

  • The targeting vector has been generated using 129SvEv DNA and transfected into 129SvEv ES cell line.
  • The H101R point mutation was introduced into Gabra1 exon 4.
  • The neomycin resistance cassette, which is flanked by loxP sites, was introduced into intron 3.
  • Chimeric mice were produced and germ line transmission achieved.
  • The neomycin resistance gene has been removed in the constitutive PM mice by crossing to Cre-Deleter mice.
  • The H101R point mutation in exon 4 abolishes benzodiazepine binding of the Gabra1 H101R receptor, but keeps the Gabra1 function otherwise normal.
  • Gabra1 H101R constitutive PM mice are in a mixed C57BL/6-129SvEv genetic background.
  • See R.M. McKernan et al, Nat Neurosci. 2000 Jun;3(6):587-92, for further details.

Availability

Cryopreserved at Taconic

Source: Merck Research Laboratories

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

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Genetics

Species:Mouse
Strain Type:Outbred or Mixed
Allele Type:Point Mutation
Genetic Background:Mixed
Gene Family: Receptor
Gene Symbol: Gabra1
Gene Accession Number: NM_010250
Gene Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

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Gabra1 - Model 7088 - PM

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

    ItemCommercialNonprofit
    Cryopreserved Model$32,500$5,500
      ItemCommercialNonprofit
      Cryopreserved Model€29.500€5.005

       

      Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

      Fees for Taconic Transit Cages™ and freight are in addition to the price above.

       

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