Model No. | Nomenclature | Genotype |
---|---|---|
1480 | B6.129-Esr1tm1Ksk | Inquire for genotype |
Nomenclature: B6.129-Esr1tm1Ksk
Origin
The ERKO-α mouse was developed by Kenneth S. Korach of the NIEHS and colleagues in 1993. The model was created by targeting the Esr1 gene in E12TG2a ES cells and injecting the targeted ES cells into C57BL/6J blastocysts. Resultant chimeras were backcrossed to C57BL/6 for ten generations (N10). Taconic received stock from the NIEHS in 1998, and animals were transferred to Taconic for commercial production in 2000. Homozygotes and heterozygotes were generated through HET x HET matings.
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Initial Publication:
Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O. (1993) Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. PNAS USA, 90:11162-6.
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Item | Commercial | Nonprofit |
---|---|---|
Cryopreserved Model | $23,100.00 | $17,325.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Item | Commercial | Nonprofit |
---|---|---|
Cryopreserved Model | €21.000,00 | €15.855,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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