Fecal Microbiota Transplantation Service

Microscopic Image of Fecal MicrobiotaTaconic Biosciences' germ-free mice are an ideal substrate to evaluate the properties of complex or defined gut microbiota following fecal microbiota transplantation (FMT). Axenic (germ-free) mice transplanted with donor microbiota can be utilized to assess the effects of gut bacteria on a wide range of biological systems, including but not limited to, immunity, neurodegenerative diseases, obesity and diabetes.

“Seres relies on Taconic's germ-free mice to study the microbiome and our drug candidates”
Using client-provided FMT materials, microbiota are administered by oral gavage to germ-free mice under aseptic conditions at Taconic's Isolator Breeding Solutions facility. Following FMT, the health status of animals is expected to be a Germ Free background overlayed with organisms from the donor material. During the husbandry period, Taconic will initiate microbiological monitoring practices.

Taconic Biosciences' custom FMT service:

  • Germ-free mice are associated with client-provided microbiota
  • Range of available husbandry options for large or small study cohorts and short or long-term animal studies including semi-rigid isolators and Individually Ventilated Cages (IVCs)
  • Utilizes Taconic's commercially available Germ Free C57BL/6 and Germ Free Swiss Webster strains
  • Custom Germ Free derivations are available for client lines or GEMs to generate axenic stock
  • Biospecimen collections
  • Shipment of conditioned animals or samples to client or CRO at study end
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