Trex1 Knockout Mouse

Constitutive Knockout

Trex1 Constitutive Knockout Mouse Model
EZcohort® Models
The easiest way to acquire and breed cryopreserved GEMs
This model is available for immediate cryorecovery.

B6;129 Background

  • Model #
  • Genotype
  • Nomenclature
  • 13076
  • Constitutive knockout of the three prime repair exonuclease I gene (Trex1)
  • Model of Aicardi-Goutieres syndrome
  • Displays inflammatory myocarditis and autoimmune disease
  • Homozygous knockouts have a reduced lifespan


The Trex1 Knockout Mouse was developed in the laboratories of Tomas Lindahl at the Clare Hall Laboratories, Imperial Cancer Research Fund (now Cancer Research UK). The model was created using a targeting vector that replaced amino acids 103-207 of the Trex1 open reading frame with a neo cassette in GK129 ES cells derived from the 129P2 strain. Targeted ES cells were injected into C57BL/6J blastocysts. Taconic received frozen embryos from CRT in 2013.


Cancer Research Technology



Initial Publication:

Morita M, Stamp G, Robins P, Dulic A, Rosewell I, Hrivnak G, Daly G, Lindahl T, Barnes DE. (2004) Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis. Mol Cell Biol. 24(15):6719-27.

To purchase this EZcohort model, sign the Terms of Sale (choose from the list below) and email it directly to

This model is sold under terms which grant perpetual use rights.

Welcome! Tell us a little about yourself