Trex1 Knockout Mouse

Constitutive Knock Out

Trex1 Constitutive Knock Out Mouse Model
This line is cryopreserved and requires cryorecovery.

B6;129 Background

  • Model #
  • Genotype
  • Nomenclature
  • 13076-F
    B6;129P2-Trex1tm1Tld
  • 13076-M
    B6;129P2-Trex1tm1Tld
  • Constitutive knockout of the three prime repair exonuclease I gene (Trex1)
  • Model of Aicardi-Goutieres syndrome
  • Displays inflammatory myocarditis and autoimmune disease
  • Homozygous knockouts have a reduced lifespan

Origin:

The Trex1 Knockout Mouse was developed in the laboratories of Tomas Lindahl at the Clare Hall Laboratories, Imperial Cancer Research Fund (now Cancer Research UK). The model was created using a targeting vector that replaced amino acids 103-207 of the Trex1 open reading frame with a neo cassette in GK129 ES cells derived from the 129P2 strain. Targeted ES cells were injected into C57BL/6J blastocysts. Taconic received frozen embryos from CRT in 2013.

Source:

Cancer Research Technology

Species:

Mouse

Initial Publication:

Morita M, Stamp G, Robins P, Dulic A, Rosewell I, Hrivnak G, Daly G, Lindahl T, Barnes DE. (2004) Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis. Mol Cell Biol. 24(15):6719-27.

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