Tnfrsf18 - Model 13792 - KO

Constitutive Knockout

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 13792
  • The targeting vector has been generated using C57BL/6J DNA and transfected into Taconic's C57BL/6N Tac ES cell line.
  • Tnfrsf18 exon 1 contains the translation initiation codon.
  • Exons 1 to 5 have been replaced by the FRT site flanked neomycin resistance gene cassette.
  • The neomycin resistance gene cassette has been removed by transient transfection of Flp recombinase into targeted ES cell clones.
  • The constitutive KO line has been derived using C57BL/6NTac animals.
  • Bud31 (Edg2) constitutive KO mice are in a mixed C57BL/6-129SvEv genetic backgroundDeletion of exons 1 to 5 should result in loss of function of the Tnfrsf18 gene.
  • The remaining recombination sites are located in non-conserved regions of the genome.
  • Datamining and Design performed in 2004.

Gene Family:


Genetic Background:


Gene Symbol:


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Allele Type:





Cryopreserved at Taconic



Official Gene Name:

tumor necrosis factor receptor superfamily, member 18

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GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

  • A minimum of four (4) mice mutant for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 mutant mice.
  • Validated genotyping protocols
  • Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO. The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

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