Il13ra1 - Model 7895 - KO

Constitutive Knockout

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

  • Model #
  • Genotype
  • Nomenclature
  • 7895
    B6;129S2-IL13ra1tm1.2mrl
  • The targeting vector has been generated using C57BL/6J DNA and transfected into 129Sv/Pas ES cell line.
  • Il13ra1 exon 1 contains the translation initiation codon.
  • Exon 3 has been flanked by loxP sites.
  • The constitutive KO allele has been generated after Cre-mediated recombination by crossing chimeras to a Cre-Deleter on a C57BL/6 background.
  • The constitutive KO line has been subsequently backcrossed to C57BL/6NTac animals for at least 2 generations and the Cre-transgene was removed by segregation.
  • Deletion of exon 3 should result in loss of function of the Il13ra1 gene by generating a frame shift (premature stop codon in exon 4).
  • The remaining recombination sites are located in intron regions of the genome.
  • The constitutive KO line is also available in a congenic C57BL/6 genetic background, line 8031.
  • Datamining and Design performed in 2005.

Gene Family:

Receptor

Genetic Background:

C57BL/6; 129Sv/Pas

Gene Symbol:

Il13ra1

Gene Accession Number:

NM_133990

Allele Type:

KO

Source:

Institut Clinique de la Souris (ICS), Illkirch, France

Availability:

Cryopreserved at Taconic

Species:

Mouse

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyrc-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyrc-Brd background.

For standard orders clients will receive:

  • A minimum of four (4) Mutant Mice, heterozygous for the Selected Mutation, including at least one (1) breeding pair on a mixed 129S5;B6 background.
  • Validated genotyping protocols
  • Animal health data

Commercial Pricing:

Number of Lines PurchasedPrice per Line ($)Price per Line for Comprehensive Phenotype Data ($)
Single Line $45,000 $25,000
2 Lines $40,500 $25,000
3 Lines $39,375 $25,000
4+ Lines $38,250 $25,000

Nonprofit Pricing:

Price per Line ($)Price per Line for Comprehensive Phenotype Data ($)
$30,000 $15,000
Basic Phenotype Package: $5,000
Multi-line discounts will be applied to lines ordered on a single purchase order (PO).

Commercial Pricing:

Number of Lines PurchasedPrice per Line (€)Price per Line for Comprehensive Phenotype Data (€)
Single Line €42,750 €23,750
2 Lines €38,475 €23,750
3 Lines €37,406 €23,750
4+ Lines €36,338 €23,750

Nonprofit Pricing:

Price per Line (€)Price per Line for Comprehensive Phenotype Data (€)
€28,500 €14,250
Basic Phenotype Package: €4,750
Multi-line discounts will be applied to lines ordered on a single purchase order (PO).
Taconic continues to strive to gain full access to all models for both nonprofit and commercial organizations. However, at this time some models are currently not available to commercial institutions. Please be sure to check back often as more models are made available on a routine basis.

Get a 10% discount by having Taconic breed the model for you. To learn more about our custom breeding solutions visit our website at https://www.taconic.com/breed-your-model.

Commercial Pricing: (MTA)

Number of Lines PurchasedPrice per Line ($)
Single Line $30,000
2 Lines $24,000

Nonprofit Pricing: (MTA)

Price per Line ($)
$4,900

Commercial Pricing: (MTA)

Number of Lines PurchasedPrice per Line (€)
Single Line €28,500
2 Lines €22,800

Nonprofit Pricing: (MTA)

Price per Line (€)
€4,655