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The targeting vector has been generated using C57BL/6J DNA and transfected into TaconicArtemis C57BL/6NTac ES cell line.
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Exon 1 contains the translation initiation codon.
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Exon3 has been flanked by loxP sites (size of loxP-flanked region: 0.5 kb).
- FRT-flanked neomycin cassette was removed by crossing with a Flp deleter mouse on the C57BL/6 background.
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The constitutive KO allele has been generated after Cre-mediated recombination by crossing chimeras to a Cre-Deleter on a C57BL/6 background.
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The constitutive KO line has been derived using C57BL/6NTac animals and the Cre-transgene was removed by segregation.
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Deletion of exon 3 should result in loss of function of the Hdac11 by generating a frameshift.
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Datamining and Design performed in 2003.
Gene Family:
Deacetylase Genetic Background:
C57BL/6 Gene Symbol:
Hdac11 Gene Accession Number:
NM_144919 Allele Type:
KO Source:
TaconicArtemis Availability:
Cryopreserved at Taconic Species:
Mouse Official Gene Name:
histone deacetylase 11
