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Gpr6 - Model 11211 - TG

Random Transgenic

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 11211
    C57BL/6-Tg(Ins2-GPR6)27 Mrl
  • The transgenic construct contains 5´ a floxed neo cassette, the 8.5 kb mouse insulin promotor (MIP), the rabbit b-globulin intron, the human GPR6 cDNA, and the SV40 polyA signal.
  • The transgenic construct was transfected into C57BL/6NTac ES cell line.
  • Copy numbers of random integrators were determined by Southern blotting.
  • The neomycin resistance cassette was removed by Cre-mediated recombination by crossing chimeras to a Cre-Deleter on a C57BL/6 background.
  • The transgenic founders were subsequently backcrossed to C57BL/6NTac animals for at least 2 generations and the Cre-transgene was removed by segregation.
  • Line 11210, M160 clone 13, contains 2-3 copies of the transgene.
  • Line 11211, M160 clone 27, contains 10-25 copies of the transgene.
  • Datamining and Design performed in 2008.

Gene Family:

G-protein coupled receptor

Genetic Background:


Gene Symbol:


Gene Accession Number:


Allele Type:



Institut Clinique de la Souris (ICS), Illkirch, France


Cryopreserved at Taconic



Official Gene Name:

G protein-coupled receptor 6

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO. The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.
GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

  • A minimum of four (4) mice mutant for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 mutant mice.
  • Validated genotyping protocols
  • Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.

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