Ggt1 - Model 9554 - TG

• The transgenic construct contains 5´ the serum albumin enhancer (822bp) and promoter (194bp), the human GGT1 cDNA, additional Kozak consensus sequence, and SV40 polyA signal at 3´ end.
• The NotI linearized transgenic construct was microinjected in C57BL6 mice by pronuclear injection.
• Putative transgenic founders were identified by genotyping and bred for germ line transmission with C57BL6 mice.
• Heterozygous transgenic mice were identified by genotyping.
• Line 9556, M135-188, has highest expression level of transgene in the liver.
• Line 9555, M135-53, has second highest expression level of the transgene in the liver.
• Line 9557, M135-161, has third highest expression level of the transgene in the liver.
• Line 9554, M135-93, has lowest expression level of the transgene in the liver.
• Datamining and Design performed in 2006.

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

• GEM Collection Commercial Terms of Sale
• GEM Collection Academic Terms of Sale

The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

• A minimum of four (4) mice mutant for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 mutant mice.
• Validated genotyping protocols
• Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.

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