A plasmid containing the human ApoA1 promoter, human β-globin intron 2 and a cDNA containing the entire ORF of the human FGF21 gene has been engineered.
The plasmid construct was microinjected in C57BL6 mice by pronuclear injection.
Putative transgenic founders were identified by genotyping and bred for germ line transmission with C57BL6 mice.
Heterozygous transgenic mice were identified by genotyping.
Line 10181, C57BL/6-Tg(APOA1-FGF21)14 Mrl
Data mining and Design performed in 2009.
Gene Family: Growth factor
Genetic Background: C57BL/6
Gene Symbol: Fgf21
Gene Accession Number: NM_020013
Allele Type: Tg
Availability: Cryopreserved at Taconic