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A plasmid containing the CMV enhancer-chicken β-actin (pCAG) promoter, rabbit b-globin intron and the human ENPP1 cDNA has been engineered.
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The plasmid construct was microinjected in C57BL6 mice by pronuclear injection.
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Putative transgenic founders were identified by genotyping and bred for germ line transmission with C57BL6 mice.
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Heterozygous transgenic mice were identified by genotyping.
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Line 10397, C57BL/6-Tg(ENPP1)M119 Mrl, has an overexpression level of the transgene in the brain, muscle and white adipose tissue compared to C57BL6 wild type organs.
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Data mining and Design performed in 2007.
Gene Family:
Phosphodiesterase Genetic Background:
C57BL/6 Gene Symbol:
Enpp1 Gene Accession Number:
NM_006208 Allele Type:
hTg Source:
Mouse Clinical Institute (MCI) Availability:
Cryopreserved at Taconic Species:
Mouse Official Gene Name:
ectonucleotide pyrophosphatase/phosphodiesterase 1