Enpp1 - Model 10397 - hTg

• A plasmid containing the CMV enhancer-chicken β-actin (pCAG) promoter, rabbit b-globin intron and the human ENPP1 cDNA has been engineered.
• The plasmid construct was microinjected in C57BL6 mice by pronuclear injection.
• Putative transgenic founders were identified by genotyping and bred for germ line transmission with C57BL6 mice.
• Heterozygous transgenic mice were identified by genotyping.
• Line 10397, C57BL/6-Tg(ENPP1)M119 Mrl, has an overexpression level of the transgene in the brain, muscle and white adipose tissue compared to C57BL6 wild type organs.
• Data mining and Design performed in 2007.

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

• GEM Collection Commercial Terms of Sale
• GEM Collection Academic Terms of Sale

The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

• A minimum of four (4) mice mutant for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 mutant mice.
• Validated genotyping protocols
• Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.

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