Emr1 - Model 13798 - KO

Constitutive Knockout

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 13798
    C57BL/6-Emr1tm1.1Mrl
  • The targeting vector has been generated using C57BL/6J DNA and transfected into C57BL/6NTac ES cell line.
  • Emr1 exon 1 contains the translation initiation codon.
  • Exons 16-17 have been flanked by loxP sites.
  • The conditional KO allele has been generated after Flp-mediated recombination by crossing chimeras to a Flp-Deleter on a C57BL/6 background.
  • The conditional KO line has been subsequently backcrossed to C57BL/6NTac animals for at least 2 generations and the Flp-transgene was removed by segregation.
  • The constitutive KO allele can be generated by Cre-mediated recombination.
  • Deletion of exons 16-17 should result in loss of function of the Emr1 gene by generating a frameshift (premature stop codon in exon 19).
  • The remaining recombination sites are located in intron regions of the genome.
  • Data mining and Design performed in 2005.

Gene Family:

Receptor

Genetic Background:

C57BL/6

Gene Symbol:

Emr1

Gene Accession Number:

NM_010130

Allele Type:

KO

Source:

MCI mol bio pac uploaded

Species:

Mouse

Official Gene Name:

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO. The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.
GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

  • A minimum of four (4) mice mutant for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 mutant mice.
  • Validated genotyping protocols
  • Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.

For Profit Pricing:

Price per Line ($)
$31,500

Nonprofit Pricing:

Price per Line ($)
$5,500

For Profit Pricing:

Price per Line (€)
€28,650

Nonprofit Pricing:

Price per Line (€)
€5,005
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