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Elovl4 - Model 13781 - Tg

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 13781
    C57BL/6-Tg(ELOVL4 mut)M69-123 Mrl
  • A plasmid containing the Human IRBP (Retinol Binding Protein 3) promoter, a Rabbit β-globin intron and the human mutant ELOVL4 cDNA harboring the AACTT deletion resulting in progressive photoreceptor degeneration has been engineered.
  • The plasmid construct was microinjected in C57BL6 mice by pronuclear injection.
  • Putative transgenic founders were identified by genotyping and bred for germ line transmission with C57BL6 mice.
  • Heterozygous transgenic mice were identified by genotyping.
  • Line 13781, C57BL/6-Tg(ELOVL4 mut)M69-123 Mrl, has 1 transgenic copy integrated and shows lowest expression level in ONL.
  • Line 13782, C57BL/6-Tg(ELOVL4 mut)M69-53 Mrl, has 2-3 transgenic copies integrated and shows intermediate expression level in ONL.
  • Line 13782, C57BL/6-Tg(ELOVL4 mut)M69-80 Mrl, has 6 transgenic copies integrated and shows highest expression level in ONL.
  • Data mining and Design performed in 2008.

Gene Family:

Synthase

Genetic Background:

C57BL/6

Gene Symbol:

Elovl4

Gene Accession Number:

NM_148941

Allele Type:

Tg

Source:

Uploaded into teamspace

Species:

Mouse

Official Gene Name:

elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO. The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.
GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

  • A minimum of four (4) mice heterozygous for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 heterozygous mice.
  • Validated genotyping protocols
  • Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.

For-Profit Pricing:

Price per Line ($)
$30,000

Non-Profit Pricing:

Price per Line ($)
$5,500

For-Profit Pricing:

Price per Line (€)
€27,300

Non-Profit Pricing:

Price per Line (€)
€5,005