-
The targeting vector has been generated using C57BL/6J DNA and transfected into TaconicArtemis C57BL/6NTac ES cell line.
-
Exon 1 contains the translation initiation codon.
-
Exon 2 has been flanked by loxP sites (size of loxP-flanked region: 0.6 kb).
-
The conditional KO allele has been generated after Flp-mediated recombination by crossing chimeras to a Flp-Deleter on a C57BL/6 background.
-
The conditional KO line has been derived using C57BL/6NTac animals and the Flp-transgene was removed by segregation.
-
The constitutive KO allele can be generated by Cre-mediated recombination. Deletion of exon 2 should result in loss of function of the Dkk1 gene by deleting exon2 and by generating a frameshift from exon 1 to exons 3 and 4.
-
The corresponding constitutive KO allele is available as line 6093.
-
Datamining and Design performed in 2004.
Gene Family:
Receptor ligand Genetic Background:
C57BL/6 Gene Symbol:
Dkk1 Gene Accession Number:
NM_010051 Allele Type:
cKO Source:
TaconicArtemis Availability:
Cryopreserved at Taconic
Species:
Mouse Official Gene Name:
dickkopf homolog 1 (Xenopus laevis)
