Clec5a (Mdl1) - Model 11163 - cKO

Conditional Knockout

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 11163
    C57BL/6-Clec5atm1.1Mrl
  • The targeting vector has been generated using C57BL/6J DNA and transfected into Taconic’s C57BL/6N Tac ES cell line.
  • Clec5a exon 1 contains the translation initiation codon.
  • Exons 2 to 4 have been flanked by loxP sites including the FRT site flanked neomycin resistance gene cassette.
  • The neomycin resistance gene cassette has been removed by transient transfection of Flp recombinase into targeted ES cell clones.
  • The conditional KO line has been derived using C57BL/6NTac animals.
  • The constitutive KO allele can be generated by Cre-mediated recombination. Deletion of exons 2 to 4 should result in loss of function of the Clec5a gene.
  • The remaining recombination sites are located in non-conserved regions of the genome.
  • Datamining and Design performed in 2009.

Gene Family:

Lectin

Genetic Background:

C57BL/6

Gene Symbol:

Clec5a (Mdl1)

Gene Accession Number:

NM_001038604

Allele Type:

cKO

Source:

Xenogen

Availability:

Cryopreserved at Taconic

Species:

Mouse

Official Gene Name:

C-type lectin domain family 5, member a

For Profit Pricing:

Price per Line ($)
$30,000

Nonprofit Pricing:

Price per Line ($)
$5,500

For Profit Pricing:

Price per Line (€)
€27,300

Nonprofit Pricing:

Price per Line (€)
€5,005
GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

  • A minimum of four (4) mice mutant for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 mutant mice.
  • Validated genotyping protocols
  • Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO. The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.
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